› 2r32

X-ray diffraction
1.95Å resolution

Crystal Structure of human GITRL variant

Released:
DOI: 10.2210/pdb2r32/pdb
PDB entry 2r32 coloured by chain, front view.
PDB entry 2r32 coloured by chain, side view.
PDB entry 2r32 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Chattopadhyay K, Ramagopal UA, Mukhopadhaya A, Malashkevich VN, Dilorenzo TP, Brenowitz M, Nathenson SG, Almo SC
Proc Natl Acad Sci U S A 104 19452-7 (2007)
PMID: 18040044

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193993 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 18 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 18.92 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UNG2 (Residues: 52-177; Coverage: 71%)
Gene names: AITRL, GITRL, TL6, TNFSF18, UNQ149/PRO175
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: R3
Unit cell:
a: 61.219Å b: 61.219Å c: 113.948Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.246
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Structural principles of tumor necrosis factor superfamily signaling.
Vanamee et al. (2018)
10 more

4 mentions without citation

Sequence, structure, function, immunity: structural genomics of costimulation.
Chattopadhyay et al. (2009)
3 more