› 2vcd

Solution NMR

Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin

Released:
DOI: 10.2210/pdb2vcd/pdb
PDB entry 2vcd coloured by chain, ensemble of 16 models, front view.
PDB entry 2vcd coloured by chain, ensemble of 16 models, side view.
PDB entry 2vcd coloured by chain, ensemble of 16 models, top view.
Source organism: Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Primary publication:
Solution structure of the Legionella pneumophila Mip-rapamycin complex.
Ceymann A, Horstmann M, Ehses P, Schweimer K, Paschke AK, Steinert M, Faber C
OpenAccess logo BMC Struct Biol 8 17 (2008)
PMID: 18366641

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Outer membrane protein MIP Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 14.67 KDa
Source organism: Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5ZXE0 (Residues: 97-233; Coverage: 64%)
Gene names: lpg0791, mip
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RAP 1 x RAP
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: ARIA, SIMULATED ANNEALING
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.
Ünal et al. (2014)
6 more

2 mentions without citation

Solution structure of the Legionella pneumophila Mip-rapamycin complex.
Ceymann et al. (2008)
1 more