› 2wgu

X-ray diffraction
1.8Å resolution

Structure of human adenovirus serotype 37 fibre head in complex with a sialic acid derivative, O-Methyl 5-N- methoxycarbonyl -3,5-dideoxy- D-glycero-a-D-galacto-2-nonulopyranosylonic acid

Released:
DOI: 10.2210/pdb2wgu/pdb
PDB entry 2wgu coloured by chain, front view.
PDB entry 2wgu coloured by chain, side view.
PDB entry 2wgu coloured by chain, top view.
Source organism: Human adenovirus D37
Primary publication:
Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis.
Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M
J Med Chem 52 3666-78 (2009)
PMID: 19456100

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenoviral fibre protein knob domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 194 amino acids
Theoretical weight: 21.72 KDa
Source organism: Human adenovirus D37
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q64823 (Residues: 172-365; Coverage: 53%)
Gene name: L5
Sequence domains: Adenoviral fibre protein (knob domain)
Structure domains: Adenovirus pIV-related, attachment domain

Ligands and Environments

2 bound ligands:
Ligand 42D 3 x 42D
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 61.14Å b: 69.93Å c: 74.45Å
α: 90° β: 94.35° γ: 90°
R-values:
R R work R free
0.185 0.183 0.223
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Latest insights on adenovirus structure and assembly.
San Martín C. (2012)
2 more