› 2wr7

X-ray diffraction
2.5Å resolution

the structure of influenza H2 human singapore hemagglutinin with human receptor

Released:
DOI: 10.2210/pdb2wr7/pdb
PDB entry 2wr7 coloured by chain, front view.
PDB entry 2wr7 coloured by chain, side view.
PDB entry 2wr7 coloured by chain, top view.
Source organism: Influenza A virus (A/Singapore/1/1957(H2N2))
Primary publication:
Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.
Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ
Proc Natl Acad Sci U S A 106 17175-80 (2009)
PMID: 19805083

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179290 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hemagglutinin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 506 amino acids
Theoretical weight: 57.16 KDa
Source organism: Influenza A virus (A/Singapore/1/1957(H2N2))
UniProt:
  • Canonical: Q67333 (Residues: 1-506; Coverage: 90%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GAL, NAG, SIA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 80.168Å b: 123.678Å c: 222.163Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.239 0.296

Quick links

Citations

27 review citations

Influenza A viruses: new research developments.
Medina et al. (2011)
26 more

27 mentions without citation

The sweet spot: defining virus-sialic acid interactions.
Stencel-Baerenwald et al. (2014)
26 more