2xn6

X-ray diffraction
1.29Å resolution

Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-529303 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thyroxine-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 350 amino acids
Theoretical weight: 39.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05543 (Residues: 32-377, 378-380; Coverage: 88%)
Gene names: SERPINA7, TBG
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Thyroxine-binding globulin Chain: B
Molecule details ›
Chain: B
Length: 35 amino acids
Theoretical weight: 4.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05543 (Residues: 381-415; Coverage: 9%)
Gene names: SERPINA7, TBG

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21212
Unit cell:
a: 172.69Å b: 42.14Å c: 56.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.235
Expression system: Escherichia coli BL21(DE3)