› 2xvq

X-ray diffraction
2.9Å resolution

Human serum albumin complexed with dansyl-L-sarcosine

Released:
DOI: 10.2210/pdb2xvq/pdb
PDB entry 2xvq coloured by chain, front view.
PDB entry 2xvq coloured by chain, side view.
PDB entry 2xvq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.
Ryan AJ, Ghuman J, Zunszain PA, Chung CW, Curry S
OpenAccess logo J Struct Biol 174 84-91 (2011)
PMID: 20940056

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand 9DS 2 x 9DS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P1
Unit cell:
a: 55.485Å b: 55.355Å c: 120.738Å
α: 81.15° β: 90.21° γ: 65.01°
R-values:
R R work R free
0.22 0.22 0.257
Expression system: Komagataella pastoris

Quick links

Citations

4 review citations

Interactive association of drugs binding to human serum albumin.
Yang et al. (2014)
3 more

2 mentions without citation

Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin.
Sivertsen et al. (2014)
1 more