› 2zoy

X-ray diffraction
1.9Å resolution

The multi-drug binding transcriptional repressor CgmR (CGL2612 protein) from C.glutamicum

Released:
DOI: 10.2210/pdb2zoy/pdb
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Source organism: Corynebacterium glutamicum ATCC 13032
Primary publication:
The CGL2612 protein from Corynebacterium glutamicum is a drug resistance-related transcriptional repressor: structural and functional analysis of a newly identified transcription factor from genomic DNA analysis.
Itou H, Okada U, Suzuki H, Yao M, Wachi M, Watanabe N, Tanaka I
J Biol Chem 280 38711-9 (2005)
PMID: 16166084

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 185 amino acids
Theoretical weight: 21.36 KDa
Source organism: Corynebacterium glutamicum ATCC 13032
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NMG3 (Residues: 1-177; Coverage: 100%)
Gene name: Cgl2612
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

1 bound ligand:
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P212121
Unit cell:
a: 59.754Å b: 67.051Å c: 101.326Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.232
Expression system: Escherichia coli

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Citations

2 review citations

Transcriptional regulation of gene expression in Corynebacterium glutamicum: the role of global, master and local regulators in the modular and hierarchical gene regulatory network.
Schröder et al. (2010)
1 more

1 mention without citation

The TetR family of regulators.
Cuthbertson et al. (2013)

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