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Crystal Structure of the G81A mutant of the Active Chimera of (S)-Mandelate Dehydrogenase in complex with its substrate 3-indolelactate

Source organisms:
Biochemical function: oxidoreductase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.1.99.31: (S)-mandelate dehydrogenase

Reaction catalysed:
(S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor
Systematic name:
(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase
Alternative Name(s):
  • L(+)-mandelate dehydrogenase
  • MDH

EC 1.1.3.15: (S)-2-hydroxy-acid oxidase

Reaction catalysed:
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)
Systematic name:
(S)-2-hydroxy-acid:oxygen 2-oxidoreductase
Alternative Name(s):
  • Glycolate oxidase
  • Hydroxy-acid oxidase A
  • Hydroxy-acid oxidase B
  • Hydroxyacid oxidase A
  • L-2-hydroxy acid oxidase
  • L-alpha-hydroxy acid oxidase
  • Oxidase, L-2-hydroxy acid

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01070
Domain description: FMN-dependent dehydrogenase
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase
The deposited structure of PDB entry 2a7p contains 2 copies of Pfam domain PF01070 (FMN-dependent dehydrogenase) in (S)-mandelate dehydrogenase. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR008259
Domain description: FMN-dependent alpha-hydroxy acid dehydrogenase, active site
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase
IPR000262
Domain description: FMN-dependent dehydrogenase
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase
IPR037396
Domain description: FMN hydroxy acid dehydrogenase domain
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase
IPR012133
Domain description: Alpha-hydroxy acid dehydrogenase, FMN-dependent
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. (S)-mandelate dehydrogenase; Glycolate oxidase
The deposited structure of PDB entry 2a7p contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in (S)-mandelate dehydrogenase. Showing 1 copy in chain A.

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