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Crystal Structure of Human M340H-Beta1,4-Galactosyltransferase-I (M340H-B4GAL-T1) in Complex with Pentasaccharide

Source organism: Homo sapiens
Biochemical function: glycosyltransferase activity
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 2.4.1.90: N-acetyllactosamine synthase

Reaction catalysed:
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine
Systematic name:
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Alternative Name(s):
  • Acetyllactosamine synthetase
  • Beta-1,4-galactosyltransferase
  • Beta-1-4-galactosyltransferase
  • Beta-1-4GalT
  • Beta-N-acetylglucosaminide beta-1-4-galactosyltransferase
  • Gal-T
  • Lactosamine synthase
  • Lactosamine synthetase
  • Lactose synthetase A protein
  • N-acetylglucosamine (beta-1,4)galactosyltransferase
  • N-acetyllactosamine synthetase
  • NAL synthetase
  • UDP-Gal:N-acetylglucosamine beta-1-4-galactosyltransferase
  • UDP-beta-1,4-galactosyltransferase
  • UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase
  • UDP-galactose--N-acetylglucosamine beta-D-galactosyltransferase
  • UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase
  • UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase
  • UDP-galactose-N-acetylglucosamine galactosyltransferase
  • UDP-galactose-acetylglucosamine galactosyltransferase
  • UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
  • UDP-galactose:N-acetylglucosaminide beta-1-4-galactosyltransferase
  • UDPgalactose:N-acetylglucosaminyl(beta-1-4)galactosyltransferase
  • Uridine diphosphogalactose-acetylglucosamine galactosyltransferase

EC 2.4.1.38: Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

Reaction catalysed:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Systematic name:
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Alternative Name(s):
  • Beta-N-acetyl-beta-1-4-galactosyltransferase
  • GalT
  • Glycoprotein 4-beta-galactosyl-transferase
  • Glycoprotein 4-beta-galactosyltransferase
  • Glycoprotein beta-galactosyltransferase
  • Thyroid galactosyltransferase
  • Thyroid glycoprotein beta-galactosyltransferase
  • UDP-galactose--glycoprotein galactosyltransferase
  • UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
  • UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase
  • UDPgalactose-glycoprotein galactosyltransferase
  • UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase
  • Uridine diphosphogalactose-glycoprotein galactosyltransferase

EC 2.4.1.275: Neolactotriaosylceramide beta-1,4-galactosyltransferase

Reaction catalysed:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Systematic name:
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Alternative Name(s):
  • Beta-4Gal-T4
  • Lactotriaosylceramide beta-1,4-galactosyltransferase
  • UDP-galactose:N-acetyl-beta-D-galactosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase

EC 2.4.1.22: Lactose synthase

Reaction catalysed:
UDP-alpha-D-galactose + D-glucose = UDP + lactose
Systematic name:
UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
Alternative Name(s):
  • Lactose synthetase
  • N-acetyllactosamine synthase
  • UDP-galactose--glucose galactosyltransferase
  • UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
  • UDP-galactose:D-glucose 4-beta-D-galactotransferase
  • Uridine diphosphogalactose-glucose galactosyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02709
Domain description: N-terminal domain of galactosyltransferase
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 2ae7 contains 3 copies of Pfam domain PF02709 (N-terminal domain of galactosyltransferase) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain A.

PF13733
Domain description: N-terminal region of glycosyl transferase group 7
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 2ae7 contains 3 copies of Pfam domain PF13733 (N-terminal region of glycosyl transferase group 7) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003859
Domain description: Beta-1,4-galactosyltransferase
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1
IPR027791
Domain description: Galactosyltransferase, C-terminal
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1
IPR027995
Domain description: Galactosyltransferase, N-terminal
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1

Structure domain

CATH CATH domain
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Processed beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 2ae7 contains 3 copies of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain A.

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