Function and Biology

Crystal structure of tryptamine-reduced aromatic amine dehydrogenase (AADH) from Alcaligenes faecalis in complex with tryptamine

Source organism: Alcaligenes faecalis
Biochemical function: aralkylamine dehydrogenase (azurin) activity
Biological process: amine metabolic process
Cellular component: periplasmic space

EC 1.4.9.2: Aralkylamine dehydrogenase (azurin)

Reaction catalysed:
ArCH(2)NH(2) + H(2)O + 2 azurin = ArCHO + NH(3) + 2 reduced azurin
Systematic name:
Aralkylamine:azurin oxidoreductase (deaminating)
Alternative Name(s):
  • Aralkylamine:(acceptor) oxidoreductase (deaminating)
  • Aromatic amine dehydrogenase
  • Arylamine dehydrogenase
  • Dehydrogenase, arylamine
  • Tyramine dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02975
Domain description: Methylamine dehydrogenase, L chain
Occurring in:
  1. Aralkylamine dehydrogenase light chain
The deposited structure of PDB entry 2agw contains 2 copies of Pfam domain PF02975 (Methylamine dehydrogenase, L chain) in Aralkylamine dehydrogenase light chain. Showing 1 copy in chain B [auth H].

PF06433
Domain description: Methylamine dehydrogenase heavy chain (MADH)
Occurring in:
  1. Aralkylamine dehydrogenase heavy chain
The deposited structure of PDB entry 2agw contains 2 copies of Pfam domain PF06433 (Methylamine dehydrogenase heavy chain (MADH)) in Aralkylamine dehydrogenase heavy chain. Showing 1 copy in chain D [auth B].

InterPro InterPro annotations
IPR036560
Domain description: Methylamine/Aralkylamine dehydrogenase light chain superfamily
Occurring in:
  1. Aralkylamine dehydrogenase light chain
IPR013504
Domain description: Methylamine/Aralkylamine dehydrogenase light chain, C-terminal domain
Occurring in:
  1. Aralkylamine dehydrogenase light chain
IPR009451
Domain description: Amine dehydrogenase heavy chain
Occurring in:
  1. Aralkylamine dehydrogenase heavy chain
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Aralkylamine dehydrogenase heavy chain
IPR011044
Domain description: Quinoprotein amine dehydrogenase, beta chain-like
Occurring in:
  1. Aralkylamine dehydrogenase heavy chain

Structure domains

CATH CATH domains
2.60.30.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Electron Transport Ethylamine Dehydrogenase
Homology: Methylamine/Aralkylamine dehydrogenase light chain
Occurring in:
  1. Aralkylamine dehydrogenase light chain
The deposited structure of PDB entry 2agw contains 2 copies of CATH domain 2.60.30.10 (Electron Transport Ethylamine Dehydrogenase) in Aralkylamine dehydrogenase light chain. Showing 1 copy in chain B [auth H].
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Aralkylamine dehydrogenase heavy chain
The deposited structure of PDB entry 2agw contains 2 copies of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Aralkylamine dehydrogenase heavy chain. Showing 1 copy in chain D [auth B].