EC 3.4.14.5: Dipeptidyl-peptidase IV
Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Alternative Name(s):
- Amino acyl-prolyl dipeptidyl aminopeptidase
- DPP IV
- DPP IV/CD26
- Dipeptidyl aminopeptidase IV
- Dipeptidyl peptidase IV
- Dipeptidyl-aminopeptidase IV
- Dipeptidyl-peptide hydrolase
- Gly-Pro naphthylamidase
- Glycoprotein GP110
- Glycylproline aminopeptidase
- Glycylprolyl aminopeptidase
- Glycylprolyl dipeptidylaminopeptidase
- Leukocyte antigen CD26
- Lymphocyte antigen CD26
- Pep X
- Post-proline dipeptidyl aminopeptidase IV
- Postproline dipeptidyl aminopeptidase IV
- T cell triggering molecule Tp103
- X-PDAP
- X-prolyl dipeptidyl aminopeptidase
- Xaa-Pro-dipeptidyl-aminopeptidase
- Xaa-Pro-dipeptidylaminopeptidase
GO terms
Biochemical function:
Biological process:
- glucagon processing
- negative regulation of neutrophil chemotaxis
- membrane fusion
- negative chemotaxis
- receptor-mediated virion attachment to host cell
- symbiont entry into host cell
- endothelial cell migration
- T cell activation
- psychomotor behavior
- locomotory exploration behavior
- regulation of cell-cell adhesion mediated by integrin
- T cell costimulation
- receptor-mediated endocytosis of virus by host cell
- peptide hormone processing
- negative regulation of extracellular matrix disassembly
- positive regulation of cell population proliferation
- cell adhesion
- proteolysis
- response to hypoxia
- behavioral fear response
Cellular component:
Sequence families
Structure domains
CATH domains
3.40.50.1820
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
alpha/beta hydrolase
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2ajl</span> contains 2 copies of CATH domain <span class='highlight'>3.40.50.1820 (Rossmann fold)</span> in <span class='highlight'>Dipeptidyl peptidase 4</span>. Showing 1 copy in chain <span class='highlight'>B [auth J]</span>. The deposited structure of PDB entry 2ajl contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Dipeptidyl peptidase 4. Showing 1 copy in chain B [auth J].](https://www.ebi.ac.uk/pdbe/static/entry/2ajl_1_J_CATH_3.40.50.1820_image-200x200.png)