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Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: canonical glycolysis
Cellular component: extracellular exosome

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EC 4.2.1.11: Phosphopyruvate hydratase

Reaction catalysed:
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
Systematic name:
2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
Alternative Name(s):
  • 14-3-2-protein
  • 2-phospho-D-glycerate hydro-lyase
  • 2-phosphoglycerate dehydratase
  • 2-phosphoglycerate enolase
  • 2-phosphoglyceric dehydratase
  • Enolase
  • Gamma-enolase
  • Nervous-system specific enolase
  • Phosphoenolpyruvate hydratase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00113
Domain description: Enolase, C-terminal TIM barrel domain
Occurring in:
  1. Gamma-enolase
The deposited structure of PDB entry 2akm contains 2 copies of Pfam domain PF00113 (Enolase, C-terminal TIM barrel domain) in Gamma-enolase. Showing 1 copy in chain A.

PF03952
Domain description: Enolase, N-terminal domain
Occurring in:
  1. Gamma-enolase
The deposited structure of PDB entry 2akm contains 2 copies of Pfam domain PF03952 (Enolase, N-terminal domain) in Gamma-enolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000941
Domain description: Enolase
Occurring in:
  1. Gamma-enolase
IPR020810
Domain description: Enolase, C-terminal TIM barrel domain
Occurring in:
  1. Gamma-enolase
IPR036849
Domain description: Enolase-like, C-terminal domain superfamily
Occurring in:
  1. Gamma-enolase
IPR029017
Domain description: Enolase-like, N-terminal
Occurring in:
  1. Gamma-enolase
IPR020809
Domain description: Enolase, conserved site
Occurring in:
  1. Gamma-enolase
IPR020811
Domain description: Enolase, N-terminal
Occurring in:
  1. Gamma-enolase

Structure domains

CATH CATH domains
3.20.20.120
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Enolase-like C-terminal domain
Occurring in:
  1. Gamma-enolase
The deposited structure of PDB entry 2akm contains 2 copies of CATH domain 3.20.20.120 (TIM Barrel) in Gamma-enolase. Showing 1 copy in chain A.
3.30.390.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Enolase-like; domain 1
Homology: Enolase-like, N-terminal domain
Occurring in:
  1. Gamma-enolase
The deposited structure of PDB entry 2akm contains 2 copies of CATH domain 3.30.390.10 (Enolase-like; domain 1) in Gamma-enolase. Showing 1 copy in chain A.
SCOP SCOP annotations
51605
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Enolase C-terminal domain-like
Occurring in:
  1. Gamma-enolase
The deposited structure of PDB entry 2akm contains 2 copies of SCOP domain 51605 (Enolase) in Gamma-enolase. Showing 1 copy in chain A.
54827
Class: Alpha and beta proteins (a+b)
Fold: Enolase N-terminal domain-like
Superfamily: Enolase N-terminal domain-like
Occurring in:
  1. Gamma-enolase
The deposited structure of PDB entry 2akm contains 2 copies of SCOP domain 54827 (Enolase N-terminal domain-like) in Gamma-enolase. Showing 1 copy in chain A.

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