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X-Ray Structure of Human Phosphomannomutase 2 (PMM2)

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: GDP-mannose biosynthetic process from glucose
Cellular component: neuronal cell body

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EC 5.4.2.8: Phosphomannomutase

Reaction catalysed:
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Systematic name:
Alpha-D-mannose 1,6-phosphomutase
Alternative Name(s):
  • D-mannose 1,6-phosphomutase
  • Mannose phosphomutase
  • Phosphomannose mutase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03332
Domain description: Eukaryotic phosphomannomutase
Occurring in:
  1. Phosphomannomutase 2
The deposited structure of PDB entry 2amy contains 1 copy of Pfam domain PF03332 (Eukaryotic phosphomannomutase) in Phosphomannomutase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005002
Domain description: Phosphomannomutase
Occurring in:
  1. Phosphomannomutase 2
IPR043169
Domain description: Phosphomannomutase, cap domain
Occurring in:
  1. Phosphomannomutase 2
IPR006379
Domain description: HAD-superfamily hydrolase, subfamily IIB
Occurring in:
  1. Phosphomannomutase 2
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Phosphomannomutase 2
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Phosphomannomutase 2

Structure domains

CATH CATH domains
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Phosphomannomutase 2
The deposited structure of PDB entry 2amy contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in Phosphomannomutase 2. Showing 1 copy in chain A.
3.30.1240.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2
Homology: Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2
Occurring in:
  1. Phosphomannomutase 2
The deposited structure of PDB entry 2amy contains 1 copy of CATH domain 3.30.1240.20 (Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2) in Phosphomannomutase 2. Showing 1 copy in chain A.
SCOP SCOP annotation
82388
Class: Alpha and beta proteins (a/b)
Fold: HAD-like
Superfamily: HAD-like
Occurring in:
  1. Phosphomannomutase 2
The deposited structure of PDB entry 2amy contains 1 copy of SCOP domain 82388 (Predicted hydrolases Cof) in Phosphomannomutase 2. Showing 1 copy in chain A.

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