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Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin.

Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versées W, Wyns L, Loris R
FEBS J 273 2407-20 (2006)
Related entries: 2ar6, 2are, 2arx, 2auy

Cited: 8 times
EuropePMC logo PMID: 16704415

Abstract

The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A.

Reviews - 2arb mentioned but not cited (1)

  1. Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi. Barre A, Bourne Y, Van Damme EJM, Rougé P. Int J Mol Sci 20 E254 (2019)


Reviews citing this publication (1)

  1. A survey of the year 2006 literature on applications of isothermal titration calorimetry. Okhrimenko O, Jelesarov I. J Mol Recognit 21 1-19 (2008)

Articles citing this publication (6)

  1. Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold. Nagae M, Soga K, Morita-Matsumoto K, Hanashima S, Ikeda A, Yamamoto K, Yamaguchi Y. Glycobiology 24 368-378 (2014)
  2. NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features. Gimeno A, Reichardt NC, Cañada FJ, Perkams L, Unverzagt C, Jiménez-Barbero J, Ardá A. ACS Chem Biol 12 1104-1112 (2017)
  3. A lectin from Platypodium elegans with unusual specificity and affinity for asymmetric complex N-glycans. Benevides RG, Ganne G, Simões Rda C, Schubert V, Niemietz M, Unverzagt C, Chazalet V, Breton C, Varrot A, Cavada BS, Imberty A. J Biol Chem 287 26352-26364 (2012)
  4. How a plant lectin recognizes high mannose oligosaccharides. Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R. Plant Physiol 144 1733-1741 (2007)
  5. Purification and characterization of a mannose/N-acetyl-D-glucosamine-specific lectin from the seeds of Platymiscium floribundum Vogel. Pereira-Junior FN, Silva HC, Freitas BT, Rocha BA, Nascimento KS, Nagano CS, Leal RB, Sampaio AH, Cavada BS. J Mol Recognit 25 443-449 (2012)
  6. Interplay between metal binding and cis/trans isomerization in legume lectins: structural and thermodynamic study of P. angolensis lectin. Garcia-Pino A, Buts L, Wyns L, Loris R. J Mol Biol 361 153-167 (2006)


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