› 2arf

Solution NMR

Solution structure of the Wilson ATPase N-domain in the presence of ATP

Released:
DOI: 10.2210/pdb2arf/pdb
PDB entry 2arf coloured by chain, ensemble of 10 models, front view.
PDB entry 2arf coloured by chain, ensemble of 10 models, side view.
PDB entry 2arf coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the N-domain of Wilson disease protein: distinct nucleotide-binding environment and effects of disease mutations.
Dmitriev O, Tsivkovskii R, Abildgaard F, Morgan CT, Markley JL, Lutsenko S
Proc Natl Acad Sci U S A 103 5302-7 (2006)
PMID: 16567646

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-543405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-transporting ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P35670 (Residues: 1032-1196; Coverage: 11%)
Gene names: ATP7B, PWD, WC1, WND
Sequence domains: haloacid dehalogenase-like hydrolase
Structure domains: Calcium-transporting ATPase, cytoplasmic domain N

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

26 review citations

Function and regulation of human copper-transporting ATPases.
Lutsenko et al. (2007)
25 more

11 mentions without citation

Structural biology of copper trafficking.
Boal et al. (2009)
10 more