› 2arj

X-ray diffraction
2.88Å resolution

CD8alpha-alpha in complex with YTS 105.18 Fab

Released:
DOI: 10.2210/pdb2arj/pdb
Model geometry
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PDB entry 2arj coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution.
Shore DA, Teyton L, Dwek RA, Rudd PM, Wilson IA
J Mol Biol 358 347-54 (2006)
PMID: 16530222

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208518 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
YTS 105.18 antigen binding region Light chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 211 amino acids
Theoretical weight: 23.41 KDa
Source organism: Rattus norvegicus
Structure domains: Immunoglobulins
YTS 105.18 antigen binding region Heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 215 amino acids
Theoretical weight: 22.97 KDa
Source organism: Rattus norvegicus
Structure domains: Immunoglobulins
T-cell surface glycoprotein CD8 alpha chain Chains: Q, R

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 83.344Å b: 107.135Å c: 131.522Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.277
Expression system: Drosophila melanogaster

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Citations

1 review citation

A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.
Moon et al. (2010)
4 other articles

8 mentions without citation

Structure, function, and immunomodulation of the CD8 co-receptor.
Srinivasan et al. (2024)
7 more

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