EC 2.7.7.7: DNA-directed DNA polymerase
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
- DNA duplicase
- DNA nucleotidyltransferase
- DNA nucleotidyltransferase (DNA-directed)
- DNA polymerase
- DNA polymerase I
- DNA polymerase II
- DNA polymerase III
- DNA polymerase alpha
- DNA polymerase beta
- DNA polymerase gamma
- DNA replicase
- DNA-dependent DNA polymerase
- Deoxynucleate polymerase
- Deoxyribonucleate nucleotidyltransferase
- Deoxyribonucleic acid duplicase
- Deoxyribonucleic acid polymerase
- Deoxyribonucleic duplicase
- Deoxyribonucleic polymerase
- Deoxyribonucleic polymerase I
- Duplicase
- Klenow fragment
- Sequenase
- Taq DNA polymerase
- Taq Pol I
- Tca DNA polymerase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Structure domains
CATH domains
3.30.70.270
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Alpha-Beta Plaits
Homology:
Alpha-Beta Plaits
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2atl</span> contains 2 copies of CATH domain <span class='highlight'>3.30.70.270 (Alpha-Beta Plaits)</span> in <span class='highlight'>DNA polymerase IV</span>. Showing 1 copy in chain <span class='highlight'>E [auth A]</span>. The deposited structure of PDB entry 2atl contains 2 copies of CATH domain 3.30.70.270 (Alpha-Beta Plaits) in DNA polymerase IV. Showing 1 copy in chain E [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2atl_3_A_CATH_3.30.70.270_image-200x200.png)
3.30.1490.100
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Dna Ligase; domain 1
Homology:
DNA polymerase, Y-family, little finger domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2atl</span> contains 2 copies of CATH domain <span class='highlight'>3.30.1490.100 (Dna Ligase; domain 1)</span> in <span class='highlight'>DNA polymerase IV</span>. Showing 1 copy in chain <span class='highlight'>E [auth A]</span>. The deposited structure of PDB entry 2atl contains 2 copies of CATH domain 3.30.1490.100 (Dna Ligase; domain 1) in DNA polymerase IV. Showing 1 copy in chain E [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2atl_3_A_CATH_3.30.1490.100_image-200x200.png)
1.10.150.20
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
DNA polymerase; domain 1
Homology:
5' to 3' exonuclease, C-terminal subdomain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2atl</span> contains 2 copies of CATH domain <span class='highlight'>1.10.150.20 (DNA polymerase; domain 1)</span> in <span class='highlight'>DNA polymerase IV</span>. Showing 1 copy in chain <span class='highlight'>E [auth A]</span>. The deposited structure of PDB entry 2atl contains 2 copies of CATH domain 1.10.150.20 (DNA polymerase; domain 1) in DNA polymerase IV. Showing 1 copy in chain E [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2atl_3_A_CATH_1.10.150.20_image-200x200.png)
SCOP annotations
100880
Class:
Alpha and beta proteins (a+b)
Fold:
Lesion bypass DNA polymerase (Y-family), little finger domain
Superfamily:
Lesion bypass DNA polymerase (Y-family), little finger domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2atl</span> contains 2 copies of SCOP domain <span class='highlight'>100880 (Lesion bypass DNA polymerase (Y-family), little finger domain)</span> in <span class='highlight'>DNA polymerase IV</span>. Showing 1 copy in chain <span class='highlight'>E [auth A]</span>. The deposited structure of PDB entry 2atl contains 2 copies of SCOP domain 100880 (Lesion bypass DNA polymerase (Y-family), little finger domain) in DNA polymerase IV. Showing 1 copy in chain E [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2atl_3_A_SCOP_100880_image-200x200.png)
100888
Class:
Multi-domain proteins (alpha and beta)
Fold:
DNA/RNA polymerases
Superfamily:
DNA/RNA polymerases
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2atl</span> contains 2 copies of SCOP domain <span class='highlight'>100888 (Lesion bypass DNA polymerase (Y-family), catalytic domain)</span> in <span class='highlight'>DNA polymerase IV</span>. Showing 1 copy in chain <span class='highlight'>E [auth A]</span>. The deposited structure of PDB entry 2atl contains 2 copies of SCOP domain 100888 (Lesion bypass DNA polymerase (Y-family), catalytic domain) in DNA polymerase IV. Showing 1 copy in chain E [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2atl_3_A_SCOP_100888_image-200x200.png)