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Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer

Source organism: Homo sapiens
Biochemical function: protein dimerization activity
Biological process: regulation of transcription by RNA polymerase II
Cellular component: transcription regulator complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF16421
Domain description: E2F transcription factor CC-MB domain
Occurring in:
  1. Transcription factor E2F1
The deposited structure of PDB entry 2aze contains 1 copy of Pfam domain PF16421 (E2F transcription factor CC-MB domain) in Transcription factor E2F1. Showing 1 copy in chain B.

PF08781
Domain description: Transcription factor DP
Occurring in:
  1. Transcription factor Dp-1
The deposited structure of PDB entry 2aze contains 1 copy of Pfam domain PF08781 (Transcription factor DP) in Transcription factor Dp-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014889
Domain description: Transcription factor DP, C-terminal
Occurring in:
  1. Transcription factor Dp-1
IPR032198
Domain description: E2F transcription factor, CC-MB domain
Occurring in:
  1. Transcription factor E2F1
IPR037241
Domain description: E2F-DP heterodimerization region
Occurring in:
  1. Transcription factor Dp-1
  2. Transcription factor E2F1
IPR015030
Domain description: Retinoblastoma-associated protein, C-terminal
Occurring in:
  1. Retinoblastoma-associated protein
IPR015633
Domain description: E2F Family
Occurring in:
  1. Transcription factor E2F1
IPR015648
Domain description: Transcription factor DP
Occurring in:
  1. Transcription factor Dp-1
IPR038168
Domain description: Transcription factor DP, C-terminal domain superfamily
Occurring in:
  1. Transcription factor Dp-1

Structure domains

CATH CATH domains
6.10.250.530
Class: Special
Architecture: Helix non-globular
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Retinoblastoma-associated protein
The deposited structure of PDB entry 2aze contains 1 copy of CATH domain 6.10.250.530 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Retinoblastoma-associated protein. Showing 1 copy in chain C.
6.10.250.540
Class: Special
Architecture: Helix non-globular
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Transcription factor E2F1
The deposited structure of PDB entry 2aze contains 1 copy of CATH domain 6.10.250.540 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Transcription factor E2F1. Showing 1 copy in chain B.
1.20.140.80
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homology: Transcription factor DP
Occurring in:
  1. Transcription factor Dp-1
The deposited structure of PDB entry 2aze contains 1 copy of CATH domain 1.20.140.80 (Butyryl-CoA Dehydrogenase, subunit A; domain 3) in Transcription factor Dp-1. Showing 1 copy in chain A.
SCOP SCOP annotations
144327
Class: Peptides
Fold: Retinoblastoma-associated protein RB1 fragments
Superfamily: Retinoblastoma-associated protein RB1 fragments
Occurring in:
  1. Retinoblastoma-associated protein
The deposited structure of PDB entry 2aze contains 1 copy of SCOP domain 144327 (Retinoblastoma-associated protein RB1 fragments) in Retinoblastoma-associated protein. Showing 1 copy in chain C.
144078
Class: Multi-domain proteins (alpha and beta)
Fold: E2F-DP heterodimerization region
Superfamily: E2F-DP heterodimerization region
Occurring in:
  1. Transcription factor E2F1
The deposited structure of PDB entry 2aze contains 1 copy of SCOP domain 144078 (E2F dimerization segment) in Transcription factor E2F1. Showing 1 copy in chain B.
144075
Class: Multi-domain proteins (alpha and beta)
Fold: E2F-DP heterodimerization region
Superfamily: E2F-DP heterodimerization region
Occurring in:
  1. Transcription factor Dp-1
The deposited structure of PDB entry 2aze contains 1 copy of SCOP domain 144075 (DP dimerization segment) in Transcription factor Dp-1. Showing 1 copy in chain A.

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