› 2b0s

X-ray diffraction
2.3Å resolution

Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide

Released:
DOI: 10.2210/pdb2b0s/pdb
Model geometry
Fit model/data
PDB entry 2b0s coloured by chain, front view.
PDB entry 2b0s coloured by chain, side view.
PDB entry 2b0s coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.
Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA
J Virol 80 6093-105 (2006)
PMID: 16731948

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209253 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab 2219, light chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 22.95 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Fab 2219, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Surface protein gp120 Chain: P

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand ACY 3 x ACY
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P41212
Unit cell:
a: 60.471Å b: 60.471Å c: 275.194Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.267
Expression system: Not provided

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Citations

4 review citations

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.
Kwong et al. (2012)
3 more

16 mentions without citation

Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology.
Robinson JA. (2013)
15 more