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Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by 5-octyl-2-phenoxyphenol

Source organism: Mycobacterium tuberculosis
Biochemical function: NAD+ binding
Biological process: mycolic acid biosynthetic process
Cellular component: peptidoglycan-based cell wall

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EC 1.3.1.9: Enoyl-[acyl-carrier-protein] reductase (NADH)

Reaction catalysed:
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Systematic name:
Acyl-[acyl-carrier protein]:NAD(+) oxidoreductase
Alternative Name(s):
  • Acyl-[acyl-carrier-protein]:NAD(+) oxidoreductase
  • Enoyl-ACP reductase
  • Enoyl-[acyl carrier protein] reductase
  • FabI (gene name)
  • InhA (gene name)
  • NADH-enoyl acyl carrier protein reductase
  • NADH-specific enoyl-ACP reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 2b37 contains 6 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR014358
Domain description: Enoyl-[acyl-carrier-protein] reductase (NADH)
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 2b37 contains 6 copies of CATH domain 3.40.50.720 (Rossmann fold) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain C.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 2b37 contains 6 copies of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain C.

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