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Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2

X-ray diffraction
2.3Å resolution
PDB entry 2b3r coloured by chain, front view.
PDB entry 2b3r coloured by chain, side view.
PDB entry 2b3r coloured by chain, top view.
Source organism: Mus musculus
Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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Multimeric state: monomeric
Accessible surface area: 6888.89 Å2
Buried surface area: 552.37 Å2
Dissociation area: 75.55 Å2
Dissociation energy (ΔGdiss): 10.23 kcal/mol
Dissociation entropy (TΔSdiss): 0.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178870
Assembly 2
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Assembly Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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Multimeric state: monomeric
Accessible surface area: 6810.64 Å2
Buried surface area: 543.79 Å2
Dissociation area: 71.46 Å2
Dissociation energy (ΔGdiss): 9.7 kcal/mol
Dissociation entropy (TΔSdiss): 0.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178870
Assembly 3
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Assembly Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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Multimeric state: homo tetramer
Accessible surface area: 22376.23 Å2
Buried surface area: 7213.94 Å2
Dissociation area: 234.94 Å2
Dissociation energy (ΔGdiss): 27.91 kcal/mol
Dissociation entropy (TΔSdiss): 1.74 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-178871

Macromolecules

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Chains: A, B
Length: 134 amino acids
Theoretical weight: 15.46 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61194 (Residues: 1561-1686; Coverage: 8%)
Gene names: Cpk, Pik3c2a
Pfam: C2 domain
InterPro:
CATH: C2 domain
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in PDB entry 2b3r, assembly 1, front view.
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in PDB entry 2b3r, assembly 1, side view.
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in PDB entry 2b3r, assembly 1, top view.
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