› 2b4y

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Sirtuin homolog 5

Released:
DOI: 10.2210/pdb2b4y/pdb
PDB entry 2b4y coloured by chain, front view.
PDB entry 2b4y coloured by chain, side view.
PDB entry 2b4y coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min JR, Antoshenko T, Dong A, Schuetz A, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacylase sirtuin-5, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 271 amino acids
Theoretical weight: 29.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NXA8 (Residues: 34-302; Coverage: 87%)
Gene names: SIR2L5, SIRT5
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand APR 4 x APR
Ligand EPE 4 x EPE
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P1
Unit cell:
a: 44.574Å b: 58.756Å c: 104.965Å
α: 93.5° β: 92.75° γ: 94.98°
R-values:
R R work R free
0.185 0.183 0.236
Expression system: Escherichia coli

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