PDB 2b5t structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

Biochemical function:

serine-type endopeptidase activity

Biological process:

blood coagulation

Cellular component:

extracellular region

Sequence domains:

7 more domains

Structure domain:

Serpins

Structure analysis Details

Assembly composition:

hetero pentamer (preferred)

Assembly name:

Antithrombin-III and Thrombin light chain (preferred)

PDBe Complex ID:

PDB-CPX-133148 (preferred)

Entry contents:

3 distinct polypeptide molecules

Macromolecules (7 distinct):

Thrombin light chain Chains: A, C

Molecule details ›

Chains: A, C
Length: 49 amino acids
Theoretical weight: 5.64 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:

Canonical: P00734 (Residues: 315-363; Coverage: 8%)

Gene name: F2
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain

Thrombin heavy chain Chains: B, D

Molecule details ›

Chains: B, D
Length: 259 amino acids
Theoretical weight: 29.76 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:

Canonical: P00734 (Residues: 364-622; Coverage: 43%)

Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Antithrombin-III Chain: I

Molecule details ›

Chain: I
Length: 432 amino acids
Theoretical weight: 49.09 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt: