› 2b77

X-ray diffraction
1.7Å resolution

Human transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID

Released:
DOI: 10.2210/pdb2b77/pdb
PDB entry 2b77 coloured by chain, front view.
PDB entry 2b77 coloured by chain, side view.
PDB entry 2b77 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
Adamski-Werner SL, Palaninathan SK, Sacchettini JC, Kelly JW
J Med Chem 47 355-74 (2004)
PMID: 14711308

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 3CA 2 x 3CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 43.215Å b: 85.082Å c: 64.401Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.238
Expression system: Escherichia coli

Quick links

Citations

25 review citations

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.
Johnson et al. (2012)
24 more