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Crystal structure of SUMO modified ubiquitin conjugating enzyme E2- 25K

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.2.23: E2 ubiquitin-conjugating enzyme

Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
  • UBC
  • Ubiquitin-carrier-protein E2
  • Ubiquitin-conjugating enzyme E2

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF11976
Domain description: Ubiquitin-2 like Rad60 SUMO-like
Occurring in:
  1. Small ubiquitin-related modifier 1
The deposited structure of PDB entry 2bf8 contains 1 copy of Pfam domain PF11976 (Ubiquitin-2 like Rad60 SUMO-like) in Small ubiquitin-related modifier 1. Showing 1 copy in chain B.

PF00179
Domain description: Ubiquitin-conjugating enzyme
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 K
The deposited structure of PDB entry 2bf8 contains 1 copy of Pfam domain PF00179 (Ubiquitin-conjugating enzyme) in Ubiquitin-conjugating enzyme E2 K. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000608
Domain description: Ubiquitin-conjugating enzyme E2
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 K
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR016135
Domain description: Ubiquitin-conjugating enzyme/RWD-like
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 K
IPR022617
Domain description: Rad60/SUMO-like domain
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR046332
Domain description: Small ubiquitin-related modifier 1, Ubl domain
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR023313
Domain description: Ubiquitin-conjugating enzyme, active site
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 K

Structure domains

CATH CATH domains
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Small ubiquitin-related modifier 1
The deposited structure of PDB entry 2bf8 contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Small ubiquitin-related modifier 1. Showing 1 copy in chain B.
3.10.110.10
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin Conjugating Enzyme
Homology: Ubiquitin Conjugating Enzyme
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 K
The deposited structure of PDB entry 2bf8 contains 1 copy of CATH domain 3.10.110.10 (Ubiquitin Conjugating Enzyme) in Ubiquitin-conjugating enzyme E2 K. Showing 1 copy in chain A.
SCOP SCOP annotations
54237
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: Ubiquitin-like
Occurring in:
  1. Small ubiquitin-related modifier 1
The deposited structure of PDB entry 2bf8 contains 1 copy of SCOP domain 54237 (Ubiquitin-related) in Small ubiquitin-related modifier 1. Showing 1 copy in chain B.
54496
Class: Alpha and beta proteins (a+b)
Fold: UBC-like
Superfamily: UBC-like
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 K
The deposited structure of PDB entry 2bf8 contains 1 copy of SCOP domain 54496 (UBC-related) in Ubiquitin-conjugating enzyme E2 K. Showing 1 copy in chain A.

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