2bfh › Citations

Crystal structure of basic fibroblast growth factor at 1.6 A resolution.

Ago H, Kitagawa Y, Fujishima A, Matsuura Y, Katsube Y
J Biochem 110 360-3 (1991)
Cited: 46 times
EuropePMC logo PMID: 1769963

Abstract

We have determined the crystal structures of two types of human basic fibroblast growth factor, the serine analogue and the wild-type, at 1.6 and 2.5 A resolution, respectively. Two good heavy atom derivatives were found and used for multiple isomorphous replacement phasing. The atomic coordinates were refined using the Hendrickson & Konnert program for stereochemically restrained refinement against structure factors. The crystallographic R factors were reduced to 15.3% for the serine analogue structure and 16.0% for the wild-type structure. The serine analogue and wild-type structures have been found to be almost identical, the root-mean-square deviation between the corresponding C alpha atoms being 0.11 A. Their structures are composed of twelve beta-strands forming a barrel and three loops. Their molecules have an approximate threefold internal symmetry and are similar in architecture to that of interleukin-1 beta. A possible heparin-binding site, which comprises five basic residues, Lys119, Arg120, Lys125, Lys129, and Lys135, has been revealed by calculating the electrostatic potential energy.

Articles - 2bfh mentioned but not cited (3)

  1. Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex. Venkataraman G, Raman R, Sasisekharan V, Sasisekharan R. Proc Natl Acad Sci U S A 96 3658-3663 (1999)
  2. Novel Bioluminescent Binding Assays for Ligand-Receptor Interaction Studies of the Fibroblast Growth Factor Family. Song G, Shao XX, Wu QP, Xu ZG, Liu YL, Guo ZY. PLoS One 11 e0159263 (2016)
  3. Molecular Modeling and Synthesis of Indoline-2,3-dione-Based Benzene Sulfonamide Derivatives and Their Inhibitory Activity against α-Glucosidase and α-Amylase Enzymes. Rasheed L, Rehman W, Rahim F, Ali Z, Alanazi AS, Hussain R, Khan I, Alanazi MM, Naseer M, Abdellattif MH, Hussain R, Khan S, Taha M, Ali Shah SA. ACS Omega 8 15660-15672 (2023)


Reviews citing this publication (6)

  1. Fibroblast growth factors and their receptors: an information network controlling tissue growth, morphogenesis and repair. Fernig DG, Gallagher JT. Prog Growth Factor Res 5 353-377 (1994)
  2. Diversity does make a difference: fibroblast growth factor-heparin interactions. Faham S, Linhardt RJ, Rees DC. Curr Opin Struct Biol 8 578-586 (1998)
  3. Fibroblast growth factors and their receptors in hematopoiesis and hematological tumors. Moroni E, Dell'Era P, Rusnati M, Presta M. J Hematother Stem Cell Res 11 19-32 (2002)
  4. The Saga of Endocrine FGFs. Phan P, Saikia BB, Sonnaila S, Agrawal S, Alraawi Z, Kumar TKS, Iyer S. Cells 10 2418 (2021)
  5. Heart-specific expression of FGF-16 and a potential role in postnatal cardioprotection. Wang J, Sontag D, Cattini PA. Cytokine Growth Factor Rev 26 59-66 (2015)
  6. Protein engineering as a tool for crystallography. Price SR, Nagai K. Curr Opin Biotechnol 6 425-430 (1995)

Articles citing this publication (37)

  1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J. Proc Natl Acad Sci U S A 93 9850-9857 (1996)
  2. A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases. Freudenberg U, Hermann A, Welzel PB, Stirl K, Schwarz SC, Grimmer M, Zieris A, Panyanuwat W, Zschoche S, Meinhold D, Storch A, Werner C. Biomaterials 30 5049-5060 (2009)
  3. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-o M, Razzaque MS, Mohammadi M. J Biol Chem 287 29134-29146 (2012)
  4. Formulation design of acidic fibroblast growth factor. Tsai PK, Volkin DB, Dabora JM, Thompson KC, Bruner MW, Gress JO, Matuszewska B, Keogan M, Bondi JV, Middaugh CR. Pharm Res 10 649-659 (1993)
  5. Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. Venkataraman G, Sasisekharan V, Herr AB, Ornitz DM, Waksman G, Cooney CL, Langer R, Sasisekharan R. Proc Natl Acad Sci U S A 93 845-850 (1996)
  6. Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil. Brych SR, Blaber SI, Logan TM, Blaber M. Protein Sci 10 2587-2599 (2001)
  7. Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor. Zhu X, Hsu BT, Rees DC. Structure 1 27-34 (1993)
  8. Bivalent carbohydrate binding is required for biological activity of Clitocybe nebularis lectin (CNL), the N,N'-diacetyllactosediamine (GalNAcβ1-4GlcNAc, LacdiNAc)-specific lectin from basidiomycete C. nebularis. Pohleven J, Renko M, Magister Š, Smith DF, Künzler M, Štrukelj B, Turk D, Kos J, Sabotič J. J Biol Chem 287 10602-10612 (2012)
  9. Docking server for the identification of heparin binding sites on proteins. Mottarella SE, Beglov D, Beglova N, Nugent MA, Kozakov D, Vajda S. J Chem Inf Model 54 2068-2078 (2014)
  10. Versatile loops in mycocypins inhibit three protease families. Renko M, Sabotic J, Mihelic M, Brzin J, Kos J, Turk D. J Biol Chem 285 308-316 (2010)
  11. Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution. Eriksson AE, Cousens LS, Matthews BW. Protein Sci 2 1274-1284 (1993)
  12. Structural basis of trypsin inhibition and entomotoxicity of cospin, serine protease inhibitor involved in defense of Coprinopsis cinerea fruiting bodies. Sabotič J, Bleuler-Martinez S, Renko M, Avanzo Caglič P, Kallert S, Štrukelj B, Turk D, Aebi M, Kos J, Künzler M. J Biol Chem 287 3898-3907 (2012)
  13. Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution. Chang BS, Beauvais RM, Arakawa T, Narhi LO, Dong A, Aparisio DI, Carpenter JF. Biophys J 71 3399-3406 (1996)
  14. The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets. Kato Y, Muto T, Tomura T, Tsumura H, Watarai H, Mikayama T, Ishizaka K, Kuroki R. Proc Natl Acad Sci U S A 93 3007-3010 (1996)
  15. Enhanced stability of recombinant keratinocyte growth factor by mutagenesis. Hsu E, Osslund T, Nybo R, Chen BL, Kenney WC, Morris CF, Arakawa T, Narhi LO. Protein Eng Des Sel 19 147-153 (2006)
  16. 1H, 15N, 13C and 13CO assignments and secondary structure determination of basic fibroblast growth factor using 3D heteronuclear NMR spectroscopy. Moy FJ, Seddon AP, Campbell EB, Böhlen P, Powers R. J Biomol NMR 6 245-254 (1995)
  17. Effects of fibroblast growth factor 9 (FGF9) on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells. Schreiber NB, Spicer LJ. Endocrinology 153 4491-4501 (2012)
  18. Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor. Hansen D, Macedo-Ribeiro S, Veríssimo P, Yoo Im S, Sampaio MU, Oliva ML. Biochem Biophys Res Commun 360 735-740 (2007)
  19. Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides. Kinsella L, Chen HL, Smith JA, Rudland PS, Fernig DG. Glycoconj J 15 419-422 (1998)
  20. Susceptibility towards intramolecular disulphide-bond formation affects conformational stability and folding of human basic fibroblast growth factor. Estapé D, van den Heuvel J, Rinas U. Biochem J 335 ( Pt 2) 343-349 (1998)
  21. A common sequence-associated physicochemical feature for proteins of beta-trefoil family. Xu R, Xiao Y. Comput Biol Chem 29 79-82 (2005)
  22. Stabilization of basic fibroblast growth factor with dextran sulfate. Kajio T, Kawahara K, Kato K. FEBS Lett 306 243-246 (1992)
  23. Absolute on-line molecular mass analysis of basic fibroblast growth factor and its multimers by reversed-phase liquid chromatography with multi-angle laser light scattering detection. Astafieva IV, Eberlein GA, Wang YJ. J Chromatogr A 740 215-229 (1996)
  24. Structural insights into the interaction of human S100B and basic fibroblast growth factor (FGF2): Effects on FGFR1 receptor signaling. Gupta AA, Chou RH, Li H, Yang LW, Yu C. Biochim Biophys Acta 1834 2606-2619 (2013)
  25. Improved Modeling of Cation-π and Anion-Ring Interactions Using the Drude Polarizable Empirical Force Field for Proteins. Lin FY, MacKerell AD. J Comput Chem 41 439-448 (2020)
  26. Silk fibroin sponges with cell growth-promoting activity induced by genetically fused basic fibroblast growth factor. Kambe Y, Kojima K, Tamada Y, Tomita N, Kameda T. J Biomed Mater Res A 104 82-93 (2016)
  27. Biophysical characterization of structural properties and folding of interleukin-1 receptor antagonist. Latypov RF, Harvey TS, Liu D, Bondarenko PV, Kohno T, Fachini RA, Rosenfeld RD, Ketchem RR, Brems DN, Raibekas AA. J Mol Biol 368 1187-1201 (2007)
  28. Arg-27, Arg-127 and Arg-155 in the beta-trefoil protein barley alpha-amylase/subtilisin inhibitor are interface residues in the complex with barley alpha-amylase 2. Rodenburg KW, Várallyay E, Svendsen I, Svensson B. Biochem J 309 ( Pt 3) 969-976 (1995)
  29. Identification of polyoxometalates as inhibitors of basic fibroblast growth factor. Pu F, Wang E, Jiang H, Ren J. Mol Biosyst 9 113-120 (2013)
  30. The importance of Arg40 and 45 in the mitogenic activity and structural stability of basic fibroblast growth factor: effects of acidic amino acid substitutions. Arakawa T, Holst P, Narhi LO, Philo JS, Wen J, Prestrelski SJ, Zhu X, Rees DC, Fox GM. J Protein Chem 14 263-274 (1995)
  31. Ca2+-saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors. Mahling R, Rahlf CR, Hansen SC, Hayden MR, Shea MA. J Biol Chem 296 100458 (2021)
  32. Three-dimensional structure of GlcNAcalpha1-4Gal releasing endo-beta-galactosidase from Clostridium perfringens. Tempel W, Liu ZJ, Horanyi PS, Deng L, Lee D, Newton MG, Rose JP, Ashida H, Li SC, Li YT, Wang BC. Proteins 59 141-144 (2005)
  33. Characterization of cDNA encoding basic fibroblast growth factor of the marsupial Monodelphis domestica. Kusewitt DF, Sabourin CL, Budge CL, Sherburn TE, Ley RD. DNA Cell Biol 13 549-554 (1994)
  34. Structural observation of complexes of FGF-2 and regioselectively desulfated heparin in aqueous solutions. Yuguchi Y, Kominato R, Ban T, Urakawa H, Kajiwara K, Takano R, Kamei K, Hara S. Int J Biol Macromol 35 19-25 (2005)
  35. Fifty years of Protein Data Bank in the Journal of Biochemistry. Kurisu G. J Biochem 171 3-11 (2022)
  36. Pharmacokinetics of recombinant human basic fibroblast growth factor in mice using a radioiodination method combined with SDS-PAGE and a sandwich enzyme-linked immunosorbent assay. Zhang Q, Wang GJ, Sun JG. Eur J Drug Metab Pharmacokinet 29 163-168 (2004)
  37. Understanding the molecular basis of stability in Kunitz (STI) family of inhibitors in terms of a conserved core tryptophan residue: A theoretical investigation. Datta Sharma R, Goswami N, Ghosh D, Majumder S. J Mol Graph Model 75 233-240 (2017)


Quick links