› 2bji

X-ray diffraction
1.24Å resolution

High Resolution Structure of myo-Inositol Monophosphatase, The Target of Lithium Therapy

Released:
DOI: 10.2210/pdb2bji/pdb
PDB entry 2bji coloured by chain, front view.
PDB entry 2bji coloured by chain, side view.
PDB entry 2bji coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy.
Gill R, Mohammed F, Badyal R, Coates L, Erskine P, Thompson D, Cooper J, Gore M, Wood S
Acta Crystallogr D Biol Crystallogr 61 545-55 (2005)
PMID: 15858264

Function and Biology Details

Reactions catalysed: 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 277 amino acids
Theoretical weight: 30.09 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20456 (Residues: 1-277; Coverage: 100%)
Gene names: IMPA, IMPA1
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P1
Unit cell:
a: 47.23Å b: 55.15Å c: 60.88Å
α: 67.22° β: 69.65° γ: 85.14°
R-values:
R R work R free
0.153 not available 0.191
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

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Fry et al. (2007)
3 more

8 mentions without citation

Discovering structural motifs using a structural alphabet: application to magnesium-binding sites.
Dudev et al. (2007)
7 more