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Crystal structure of factor Xa in complex with 50

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.6: Coagulation factor Xa

Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Systematic name:
-
Alternative Name(s):
  • Activated Stuart-Prower factor
  • Activated blood-coagulation factor X
  • Activated factor X
  • Autoprothrombin C
  • Factor Xa
  • Plasma thromboplastin
  • Prothrombase
  • Prothrombinase
  • Stuart factor
  • Thrombokinase
  • Thromboplastin

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Activated factor Xa heavy chain
The deposited structure of PDB entry 2bmg contains 1 copy of Pfam domain PF00089 (Trypsin) in Activated factor Xa heavy chain. Showing 1 copy in chain B.

PF14670
Domain description: Coagulation Factor Xa inhibitory site
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 2bmg contains 1 copy of Pfam domain PF14670 (Coagulation Factor Xa inhibitory site) in Factor X light chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Activated factor Xa heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Activated factor Xa heavy chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Activated factor Xa heavy chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Activated factor Xa heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Activated factor Xa heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Activated factor Xa heavy chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Activated factor Xa heavy chain
The deposited structure of PDB entry 2bmg contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Activated factor Xa heavy chain. Showing 2 copies in chain B.
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 2bmg contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Factor X light chain. Showing 1 copy in chain A.
SCOP SCOP annotations
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Activated factor Xa heavy chain
The deposited structure of PDB entry 2bmg contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Activated factor Xa heavy chain. Showing 1 copy in chain B.
57197
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 2bmg contains 1 copy of SCOP domain 57197 (EGF-type module) in Factor X light chain. Showing 1 copy in chain A.

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