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Crystal Structure Of Protocatechuate 3,4-Dioxygenase from Acinetobacter Sp. ADP1 Mutant R457S - APO

Source organism: Acinetobacter baylyi ADP1
Biochemical function: dioxygenase activity
Biological process: beta-ketoadipate pathway
Cellular component: not assigned

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EC 1.13.11.3: Protocatechuate 3,4-dioxygenase

Reaction catalysed:
3,4-dihydroxybenzoate + O(2) = 3-carboxy-cis,cis-muconate
Systematic name:
Protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)
Alternative Name(s):
  • Protocatechuate oxygenase
  • Protocatechuic 3,4-dioxygenase
  • Protocatechuic 3,4-oxygenase
  • Protocatechuic acid oxidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00775
Domain description: Dioxygenase
Occurring in:
  1. Protocatechuate 3,4-dioxygenase alpha chain
  2. Protocatechuate 3,4-dioxygenase beta chain
The deposited structure of PDB entry 2but contains 1 copy of Pfam domain PF00775 (Dioxygenase) in Protocatechuate 3,4-dioxygenase alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 2but contains 1 copy of Pfam domain PF00775 (Dioxygenase) in Protocatechuate 3,4-dioxygenase beta chain. Showing 1 copy in chain B.

PF12391
Domain description: Protocatechuate 3,4-dioxygenase beta subunit N terminal
Occurring in:
  1. Protocatechuate 3,4-dioxygenase beta chain
The deposited structure of PDB entry 2but contains 1 copy of Pfam domain PF12391 (Protocatechuate 3,4-dioxygenase beta subunit N terminal) in Protocatechuate 3,4-dioxygenase beta chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000627
Domain description: Intradiol ring-cleavage dioxygenase, C-terminal
Occurring in:
  1. Protocatechuate 3,4-dioxygenase alpha chain
  2. Protocatechuate 3,4-dioxygenase beta chain
IPR015889
Domain description: Intradiol ring-cleavage dioxygenase, core
Occurring in:
  1. Protocatechuate 3,4-dioxygenase alpha chain
  2. Protocatechuate 3,4-dioxygenase beta chain
IPR012785
Domain description: Protocatechuate 3,4-dioxygenase, beta subunit
Occurring in:
  1. Protocatechuate 3,4-dioxygenase beta chain
IPR012786
Domain description: Protocatechuate 3,4-dioxygenase, alpha subunit
Occurring in:
  1. Protocatechuate 3,4-dioxygenase alpha chain
IPR024756
Domain description: Protocatechuate 3,4-dioxygenase beta subunit, N-terminal
Occurring in:
  1. Protocatechuate 3,4-dioxygenase beta chain

Structure domain

CATH CATH domain
2.60.130.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Protocatechuate 3,4-Dioxygenase, subunit A
Homology: Aromatic compound dioxygenase
Occurring in:
  1. Protocatechuate 3,4-dioxygenase alpha chain
  2. Protocatechuate 3,4-dioxygenase beta chain
The deposited structure of PDB entry 2but contains 1 copy of CATH domain 2.60.130.10 (Protocatechuate 3,4-Dioxygenase, subunit A) in Protocatechuate 3,4-dioxygenase alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 2but contains 1 copy of CATH domain 2.60.130.10 (Protocatechuate 3,4-Dioxygenase, subunit A) in Protocatechuate 3,4-dioxygenase beta chain. Showing 1 copy in chain B.
SCOP SCOP annotation
49483
Class: All beta proteins
Fold: Prealbumin-like
Superfamily: Aromatic compound dioxygenase
Occurring in:
  1. Protocatechuate 3,4-dioxygenase alpha chain
  2. Protocatechuate 3,4-dioxygenase beta chain
The deposited structure of PDB entry 2but contains 1 copy of SCOP domain 49483 (Aromatic compound dioxygenase) in Protocatechuate 3,4-dioxygenase alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 2but contains 1 copy of SCOP domain 49483 (Aromatic compound dioxygenase) in Protocatechuate 3,4-dioxygenase beta chain. Showing 1 copy in chain B.

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