› 2bwq

X-ray diffraction
1.41Å resolution

Crystal Structure of the RIM2 C2A-domain at 1.4 angstrom Resolution

Released:
DOI: 10.2210/pdb2bwq/pdb
PDB entry 2bwq coloured by chain, front view.
PDB entry 2bwq coloured by chain, side view.
PDB entry 2bwq coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.
Dai H, Tomchick DR, García J, Südhof TC, Machius M, Rizo J
Biochemistry 44 13533-42 (2005)
PMID: 16216076

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulating synaptic membrane exocytosis protein 2 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 15.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9JIS1 (Residues: 725-869; Coverage: 8%)
  • Best match: Q9JIS1-2 (Residues: 772-900)
Gene names: Rim2, Rims2
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 25.455Å b: 44.807Å c: 55.756Å
α: 90° β: 103.86° γ: 90°
R-values:
R R work R free
0.183 0.181 0.213
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Synaptic vesicle fusion.
Rizo et al. (2008)
4 more

3 mentions without citation

Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).
Premkumar et al. (2010)
2 more