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Asp260Ala Escherichia coli Aminopeptidase P

Source organism: Escherichia coli
Biochemical function: metalloaminopeptidase activity
Biological process: protein homotetramerization
Cellular component: protein-containing complex

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EC 3.4.11.9: Xaa-Pro aminopeptidase

Reaction catalysed:
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Alternative Name(s):
  • Aminoacylproline aminopeptidase
  • Aminopeptidase P
  • Proline aminopeptidase
  • X-Pro aminopeptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00557
Domain description: Metallopeptidase family M24
Occurring in:
  1. Xaa-Pro aminopeptidase
The deposited structure of PDB entry 2bwt contains 1 copy of Pfam domain PF00557 (Metallopeptidase family M24) in Xaa-Pro aminopeptidase. Showing 1 copy in chain A.

PF05195
Domain description: Aminopeptidase P, N-terminal domain
Occurring in:
  1. Xaa-Pro aminopeptidase
The deposited structure of PDB entry 2bwt contains 1 copy of Pfam domain PF05195 (Aminopeptidase P, N-terminal domain) in Xaa-Pro aminopeptidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036005
Domain description: Creatinase/aminopeptidase-like
Occurring in:
  1. Xaa-Pro aminopeptidase
IPR007865
Domain description: Aminopeptidase P, N-terminal
Occurring in:
  1. Xaa-Pro aminopeptidase
IPR029149
Domain description: Creatinase/Aminopeptidase P/Spt16, N-terminal
Occurring in:
  1. Xaa-Pro aminopeptidase
IPR001131
Domain description: Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
Occurring in:
  1. Xaa-Pro aminopeptidase
IPR000994
Domain description: Peptidase M24
Occurring in:
  1. Xaa-Pro aminopeptidase

Structure domains

CATH CATH domains
3.90.230.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Creatine Amidinohydrolase
Homology: Creatinase/methionine aminopeptidase superfamily
Occurring in:
  1. Xaa-Pro aminopeptidase
The deposited structure of PDB entry 2bwt contains 1 copy of CATH domain 3.90.230.10 (Creatine Amidinohydrolase) in Xaa-Pro aminopeptidase. Showing 1 copy in chain A.
3.40.350.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Creatine Amidinohydrolase; Chain A, domain 1
Homology: Creatinase/prolidase N-terminal domain
Occurring in:
  1. Xaa-Pro aminopeptidase
The deposited structure of PDB entry 2bwt contains 1 copy of CATH domain 3.40.350.10 (Creatine Amidinohydrolase; Chain A, domain 1) in Xaa-Pro aminopeptidase. Showing 1 copy in chain A.
SCOP SCOP annotations
55921
Class: Alpha and beta proteins (a+b)
Fold: Creatinase/aminopeptidase
Superfamily: Creatinase/aminopeptidase
Occurring in:
  1. Xaa-Pro aminopeptidase
The deposited structure of PDB entry 2bwt contains 1 copy of SCOP domain 55921 (Creatinase/aminopeptidase) in Xaa-Pro aminopeptidase. Showing 1 copy in chain A.
53093
Class: Alpha and beta proteins (a/b)
Fold: Ribonuclease H-like motif
Superfamily: Creatinase/prolidase N-terminal domain
Occurring in:
  1. Xaa-Pro aminopeptidase
The deposited structure of PDB entry 2bwt contains 1 copy of SCOP domain 53093 (Creatinase/prolidase N-terminal domain) in Xaa-Pro aminopeptidase. Showing 1 copy in chain A.

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