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Inhibitor cystine knot protein McoEeTI fused to the catalytically inactive barnase mutant H102A

Source organisms:
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00299
Domain description: Squash family serine protease inhibitor
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
The deposited structure of PDB entry 2c4b contains 4 copies of Pfam domain PF00299 (Squash family serine protease inhibitor) in Ribonuclease. Showing 2 copies in chain A.

PF00545
Domain description: ribonuclease
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
The deposited structure of PDB entry 2c4b contains 2 copies of Pfam domain PF00545 (ribonuclease) in Ribonuclease. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001887
Domain description: Barnase
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
IPR000737
Domain description: Proteinase inhibitor I7, squash
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
IPR011052
Domain description: Proteinase/amylase inhibitor domain superfamily
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
IPR000026
Domain description: Guanine-specific ribonuclease N1-like
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
IPR016191
Domain description: Ribonuclease/ribotoxin
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2

Structure domain

CATH CATH domain
3.10.450.30
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Microbial ribonucleases
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
The deposited structure of PDB entry 2c4b contains 2 copies of CATH domain 3.10.450.30 (Nuclear Transport Factor 2; Chain: A,) in Ribonuclease. Showing 1 copy in chain A.
SCOP SCOP annotations
57028
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Plant inhibitors of proteinases and amylases
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
The deposited structure of PDB entry 2c4b contains 2 copies of SCOP domain 57028 (Plant inhibitors of proteinases and amylases) in Ribonuclease. Showing 1 copy in chain A.
81307
Class: Alpha and beta proteins (a+b)
Fold: Microbial ribonucleases
Superfamily: Microbial ribonucleases
Occurring in:
  1. Ribonuclease; Trypsin inhibitor 2
The deposited structure of PDB entry 2c4b contains 2 copies of SCOP domain 81307 (Bacterial ribonucleases) in Ribonuclease. Showing 1 copy in chain A.

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