› 2ceo

X-ray diffraction
2.8Å resolution

thyroxine-binding globulin complex with thyroxine

Released:
DOI: 10.2210/pdb2ceo/pdb
PDB entry 2ceo coloured by chain, front view.
PDB entry 2ceo coloured by chain, side view.
PDB entry 2ceo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism for the carriage and release of thyroxine in the blood.
Zhou A, Wei Z, Read RJ, Carrell RW
Proc Natl Acad Sci U S A 103 13321-6 (2006)
PMID: 16938877

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-529302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroxine-binding globulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 379 amino acids
Theoretical weight: 42.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05543 (Residues: 37-415; Coverage: 96%)
Gene names: SERPINA7, TBG
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand T44 2 x T44
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P212121
Unit cell:
a: 73.404Å b: 88.022Å c: 124.118Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.283
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Gooptu et al. (2009)
20 more

11 mentions without citation

A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity.
Marsan et al. (2020)
10 more