› 2ci3

X-ray diffraction
1.7Å resolution

Crystal Structure of Dimethylarginine dimethylaminohydrolase crystal form I

Released:
DOI: 10.2210/pdb2ci3/pdb
PDB entry 2ci3 coloured by chain, front view.
PDB entry 2ci3 coloured by chain, side view.
PDB entry 2ci3 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors.
Frey D, Braun O, Briand C, Vasák M, Grütter MG
Structure 14 901-11 (2006)
PMID: 16698551

Function and Biology Details

Reaction catalysed: 
N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Chain: A
Molecule details ›
Chain: A
Length: 284 amino acids
Theoretical weight: 31.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P56965 (Residues: 2-285; Coverage: 100%)
Gene name: DDAH1
Sequence domains: Arginine deiminase
Structure domains: L-arginine/glycine Amidinotransferase; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 40.461Å b: 79.619Å c: 44.879Å
α: 90° β: 108.52° γ: 90°
R-values:
R R work R free
0.188 0.188 0.219

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Citations

12 review citations

Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
Palm et al. (2007)
11 more