› 2cmw

X-ray diffraction
1.75Å resolution

Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine

Released:
DOI: 10.2210/pdb2cmw/pdb
PDB entry 2cmw coloured by chain, front view.
PDB entry 2cmw coloured by chain, side view.
PDB entry 2cmw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bunkoczi G, Rellos P, Das S, Savitsky P, Niesen F, Sobott F, Fedorov O, Pike ACW, von Delft F, Sundstrom M, Arrowsmith C, Edwards A, Weigelt J, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform gamma-1 Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 36.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HCP0 (Residues: 43-352; Coverage: 74%)
Gene name: CSNK1G1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand OLP 3 x OLP
Ligand PO4 1 x PO4
Ligand ACT 1 x ACT
1 modified residue:
Ligand SCS 1 x SCS

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 50.219Å b: 57.166Å c: 129.229Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.165 0.204
Expression system: Escherichia coli BL21(DE3)

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