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Solution structure of the PH domain of protein kinase C, D2 type from human

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.11.13: Protein kinase C

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (diacylglycerol-dependent)
Alternative Name(s):
  • CPKC
  • CPKC-alpha
  • CPKC-beta
  • CPKC-gamma
  • Calcium-dependent protein kinase C
  • Calcium-independent protein kinase C
  • Calcium/phospholipid dependent protein kinase
  • NPKC
  • NPKC-delta
  • NPKC-epsilon
  • NPKC-eta
  • NPKC-theta
  • PKC
  • PKC-alpha
  • PKC-beta
  • PKC-delta
  • PKC-epsilon
  • PKC-gamma
  • PKC-zeta
  • Pkc1p
  • Protein kinase C-epsilon
  • STK24

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00169
Domain description: PH domain
Occurring in:
  1. Serine/threonine-protein kinase D2
The deposited structure of PDB entry 2coa contains 1 copy of Pfam domain PF00169 (PH domain) in Serine/threonine-protein kinase D2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Serine/threonine-protein kinase D2
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase D2
IPR015727
Domain description: Protein kinase C mu-related
Occurring in:
  1. Serine/threonine-protein kinase D2

Structure domain

CATH CATH domain
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Serine/threonine-protein kinase D2
The deposited structure of PDB entry 2coa contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in Serine/threonine-protein kinase D2. Showing 1 copy in chain A.
SCOP SCOP annotation
50730
Class: All beta proteins
Fold: PH domain-like barrel
Superfamily: PH domain-like
Occurring in:
  1. Serine/threonine-protein kinase D2
The deposited structure of PDB entry 2coa contains 1 copy of SCOP domain 50730 (Pleckstrin-homology domain (PH domain)) in Serine/threonine-protein kinase D2. Showing 1 copy in chain A.

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