› 2cpl

X-ray diffraction
1.63Å resolution

SIMILARITIES AND DIFFERENCES BETWEEN HUMAN CYCLOPHILIN A AND OTHER BETA-BARREL STRUCTURES. STRUCTURAL REFINEMENT AT 1.63 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb2cpl/pdb
PDB entry 2cpl coloured by chain, front view.
PDB entry 2cpl coloured by chain, side view.
PDB entry 2cpl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Similarities and differences between human cyclophilin A and other beta-barrel structures. Structural refinement at 1.63 A resolution.
Ke H
J Mol Biol 228 539-50 (1992)
PMID: 1453463

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-549123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 43Å b: 52.6Å c: 89.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 not available
Expression system: Not provided

Quick links

Citations

9 review citations

Peptidylproline cis-trans-isomerases: immunophilins.
Galat A. (1993)
8 more

43 mentions without citation

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.
Grütter et al. (2012)
42 more