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Structure of ternary complexes of CITRATE SYNTHASE WITH D-AND L-MALATE: mechanistic implications

Source organism: Gallus gallus
Biochemical function: acyltransferase activity, acyl groups converted into alkyl on transfer
Biological process: citrate metabolic process
Cellular component: mitochondrial matrix

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EC 2.3.3.1: Citrate (Si)-synthase

Reaction catalysed:
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
Systematic name:
Acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolyzing, (pro-S)-carboxymethyl forming)
Alternative Name(s):
  • (R)-citrate synthase
  • Citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO->acetyl-CoA)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00285
Domain description: Citrate synthase, C-terminal domain
Occurring in:
  1. Citrate synthase, mitochondrial
The deposited structure of PDB entry 2csc contains 1 copy of Pfam domain PF00285 (Citrate synthase, C-terminal domain) in Citrate synthase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002020
Domain description: Citrate synthase
Occurring in:
  1. Citrate synthase, mitochondrial
IPR019810
Domain description: Citrate synthase active site
Occurring in:
  1. Citrate synthase, mitochondrial
IPR016143
Domain description: Citrate synthase-like, small alpha subdomain
Occurring in:
  1. Citrate synthase, mitochondrial
IPR016142
Domain description: Citrate synthase-like, large alpha subdomain
Occurring in:
  1. Citrate synthase, mitochondrial
IPR010109
Domain description: Citrate synthase, eukaryotic-type
Occurring in:
  1. Citrate synthase, mitochondrial
IPR036969
Domain description: Citrate synthase superfamily
Occurring in:
  1. Citrate synthase, mitochondrial

Structure domains

CATH CATH domains
1.10.580.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Citrate Synthase; domain 1
Homology: Citrate Synthase, domain 1
Occurring in:
  1. Citrate synthase, mitochondrial
The deposited structure of PDB entry 2csc contains 1 copy of CATH domain 1.10.580.10 (Citrate Synthase; domain 1) in Citrate synthase, mitochondrial. Showing 1 copy in chain A.
1.10.230.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome p450-Terp; domain 2
Homology: Cytochrome P450-Terp, domain 2
Occurring in:
  1. Citrate synthase, mitochondrial
The deposited structure of PDB entry 2csc contains 1 copy of CATH domain 1.10.230.10 (Cytochrome p450-Terp; domain 2) in Citrate synthase, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
48257
Class: All alpha proteins
Fold: Citrate synthase
Superfamily: Citrate synthase
Occurring in:
  1. Citrate synthase, mitochondrial
The deposited structure of PDB entry 2csc contains 1 copy of SCOP domain 48257 (Citrate synthase) in Citrate synthase, mitochondrial. Showing 1 copy in chain A.

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