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Structures of Yeast Ribonucleotide Reductase I

Source organism: Saccharomyces cerevisiae
Biochemical function: identical protein binding
Biological process: deoxyribonucleotide biosynthetic process
Cellular component: ribonucleoside-diphosphate reductase complex

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EC 1.17.4.1: Ribonucleoside-diphosphate reductase

Reaction catalysed:
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Systematic name:
2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
Alternative Name(s):
  • 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
  • ADP reductase
  • CDP reductase
  • NrdB (gene name)
  • NrdF (gene name)
  • NrdJ (gene name)
  • Nucleoside diphosphate reductase
  • RR
  • Ribonucleoside 5'-diphosphate reductase
  • Ribonucleoside diphosphate reductase
  • Ribonucleotide diphosphate reductase
  • Ribonucleotide reductase
  • UDP reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02867
Domain description: Ribonucleotide reductase, barrel domain
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
The deposited structure of PDB entry 2cvw contains 1 copy of Pfam domain PF02867 (Ribonucleotide reductase, barrel domain) in Ribonucleoside-diphosphate reductase large chain 1. Showing 1 copy in chain A.

PF00317
Domain description: Ribonucleotide reductase, all-alpha domain
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
The deposited structure of PDB entry 2cvw contains 1 copy of Pfam domain PF00317 (Ribonucleotide reductase, all-alpha domain) in Ribonucleoside-diphosphate reductase large chain 1. Showing 1 copy in chain A.

PF03477
Domain description: ATP cone domain
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
The deposited structure of PDB entry 2cvw contains 1 copy of Pfam domain PF03477 (ATP cone domain) in Ribonucleoside-diphosphate reductase large chain 1. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR000788
Domain description: Ribonucleotide reductase large subunit, C-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
IPR013346
Domain description: Ribonucleotide reductase, class I, alpha subunit, C-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
IPR005144
Domain description: ATP-cone domain
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
IPR013509
Domain description: Ribonucleotide reductase large subunit, N-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
IPR008926
Domain description: Ribonucleotide reductase R1 subunit, N-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
IPR039718
Domain description: Ribonucleoside-diphosphate reductase large subunit
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1

Structure domain

CATH CATH domain
3.20.70.20
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Homology: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Occurring in:
  1. Ribonucleoside-diphosphate reductase large chain 1
The deposited structure of PDB entry 2cvw contains 1 copy of CATH domain 3.20.70.20 (Anaerobic Ribonucleotide-triphosphate Reductase Large Chain) in Ribonucleoside-diphosphate reductase large chain 1. Showing 1 copy in chain A.

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