Function and Biology

ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY

Source organism: Homo sapiens
Biochemical function: growth factor activity
Biological process: positive regulation of ATP biosynthetic process
Cellular component: extracellular space

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00727
Domain description: Interleukin 4
Occurring in:
  1. Interleukin-4
The deposited structure of PDB entry 2cyk contains 1 copy of Pfam domain PF00727 (Interleukin 4) in Interleukin-4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002354
Domain description: Interleukin-4
Occurring in:
  1. Interleukin-4
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interleukin-4
IPR018096
Domain description: Interleukin-4/interleukin-13, conserved site
Occurring in:
  1. Interleukin-4
IPR001325
Domain description: Interleukin-4/interleukin-13
Occurring in:
  1. Interleukin-4

Structure domain

CATH CATH domain
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interleukin-4
The deposited structure of PDB entry 2cyk contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-4. Showing 1 copy in chain A.
SCOP SCOP annotation
47286
Class: All alpha proteins
Fold: 4-helical cytokines
Superfamily: 4-helical cytokines
Occurring in:
  1. Interleukin-4
The deposited structure of PDB entry 2cyk contains 1 copy of SCOP domain 47286 (Short-chain cytokines) in Interleukin-4. Showing 1 copy in chain A.