EC 5.2.1.8: Peptidylprolyl isomerase
Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
- Cyclophilin
- PPIase
- Peptide bond isomerase
- Peptidyl-prolyl cis-trans isomerase
- Peptidylprolyl cis-trans isomerase
- Rotamase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 2d3o contains 1 copy of Pfam domain PF00831 (Ribosomal L29 protein) in Large ribosomal subunit protein uL29. Showing 1 copy in chain D [auth W].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_4_W_Pfam_PF00831_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of Pfam domain <span class='highlight'>PF00831 (Ribosomal L29 protein)</span> in <span class='highlight'>Large ribosomal subunit protein uL29</span>. Showing 1 copy in chain <span class='highlight'>D [auth W]</span>.")
![The deposited structure of PDB entry 2d3o contains 1 copy of Pfam domain PF17136 (Ribosomal proteins 50S L24/mitochondrial 39S L24) in Large ribosomal subunit protein uL24. Showing 1 copy in chain C [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_3_S_Pfam_PF17136_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of Pfam domain <span class='highlight'>PF17136 (Ribosomal proteins 50S L24/mitochondrial 39S L24)</span> in <span class='highlight'>Large ribosomal subunit protein uL24</span>. Showing 1 copy in chain <span class='highlight'>C [auth S]</span>.")
![The deposited structure of PDB entry 2d3o contains 1 copy of Pfam domain PF00467 (KOW motif) in Large ribosomal subunit protein uL24. Showing 1 copy in chain C [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_3_S_Pfam_PF00467_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of Pfam domain <span class='highlight'>PF00467 (KOW motif)</span> in <span class='highlight'>Large ribosomal subunit protein uL24</span>. Showing 1 copy in chain <span class='highlight'>C [auth S]</span>.")
![The deposited structure of PDB entry 2d3o contains 1 copy of Pfam domain PF00276 (Ribosomal protein L23) in Large ribosomal subunit protein uL23. Showing 1 copy in chain B [auth R].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_2_R_Pfam_PF00276_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of Pfam domain <span class='highlight'>PF00276 (Ribosomal protein L23)</span> in <span class='highlight'>Large ribosomal subunit protein uL23</span>. Showing 1 copy in chain <span class='highlight'>B [auth R]</span>.")
![The deposited structure of PDB entry 2d3o contains 1 copy of Pfam domain PF05697 (Bacterial trigger factor protein (TF)) in Trigger factor. Showing 1 copy in chain E [auth 1].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_5_1_Pfam_PF05697_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of Pfam domain <span class='highlight'>PF05697 (Bacterial trigger factor protein (TF))</span> in <span class='highlight'>Trigger factor</span>. Showing 1 copy in chain <span class='highlight'>E [auth 1]</span>.")
RNA family (Rfam)
![The deposited structure of PDB entry 2d3o contains 1 copy of Rfam domain RF02541 (Bacterial large subunit ribosomal RNA) in 23S ribosomal RNA. Showing 1 copy in chain A [auth 0].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_1_0_Rfam_RF02541_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of Rfam domain <span class='highlight'>RF02541 (Bacterial large subunit ribosomal RNA)</span> in <span class='highlight'>23S ribosomal RNA</span>. Showing 1 copy in chain <span class='highlight'>A [auth 0]</span>.")
InterPro annotations
IPR012678
Domain description:
Ribosomal protein uL23/eL15/eS24 core domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.287.310
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:
![The deposited structure of PDB entry 2d3o contains 1 copy of CATH domain 1.10.287.310 (Helix Hairpins) in Large ribosomal subunit protein uL29. Showing 1 copy in chain D [auth W].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_4_W_CATH_1.10.287.310_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of CATH domain <span class='highlight'>1.10.287.310 (Helix Hairpins)</span> in <span class='highlight'>Large ribosomal subunit protein uL29</span>. Showing 1 copy in chain <span class='highlight'>D [auth W]</span>.")
3.30.70.330
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Alpha-Beta Plaits
Homology:
Alpha-Beta Plaits
Occurring in:
![The deposited structure of PDB entry 2d3o contains 1 copy of CATH domain 3.30.70.330 (Alpha-Beta Plaits) in Large ribosomal subunit protein uL23. Showing 1 copy in chain B [auth R].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_2_R_CATH_3.30.70.330_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of CATH domain <span class='highlight'>3.30.70.330 (Alpha-Beta Plaits)</span> in <span class='highlight'>Large ribosomal subunit protein uL23</span>. Showing 1 copy in chain <span class='highlight'>B [auth R]</span>.")
![The deposited structure of PDB entry 2d3o contains 1 copy of CATH domain 3.30.70.1050 (Alpha-Beta Plaits) in Trigger factor. Showing 1 copy in chain E [auth 1].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_5_1_CATH_3.30.70.1050_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of CATH domain <span class='highlight'>3.30.70.1050 (Alpha-Beta Plaits)</span> in <span class='highlight'>Trigger factor</span>. Showing 1 copy in chain <span class='highlight'>E [auth 1]</span>.")
SCOP annotations
46562
Class:
All alpha proteins
Fold:
Long alpha-hairpin
Superfamily:
Ribosomal protein L29 (L29p)
Occurring in:
![The deposited structure of PDB entry 2d3o contains 1 copy of SCOP domain 46562 (Ribosomal protein L29 (L29p)) in Large ribosomal subunit protein uL29. Showing 1 copy in chain D [auth W].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_4_W_SCOP_46562_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of SCOP domain <span class='highlight'>46562 (Ribosomal protein L29 (L29p))</span> in <span class='highlight'>Large ribosomal subunit protein uL29</span>. Showing 1 copy in chain <span class='highlight'>D [auth W]</span>.")
50105
Class:
All beta proteins
Fold:
SH3-like barrel
Superfamily:
Translation proteins SH3-like domain
Occurring in:
![The deposited structure of PDB entry 2d3o contains 1 copy of SCOP domain 50105 (Ribosomal proteins L24p and L21e) in Large ribosomal subunit protein uL24. Showing 1 copy in chain C [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_3_S_SCOP_50105_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of SCOP domain <span class='highlight'>50105 (Ribosomal proteins L24p and L21e)</span> in <span class='highlight'>Large ribosomal subunit protein uL24</span>. Showing 1 copy in chain <span class='highlight'>C [auth S]</span>.")
54190
Class:
Alpha and beta proteins (a+b)
Fold:
Ribosomal proteins S24e, L23 and L15e
Superfamily:
Ribosomal proteins S24e, L23 and L15e
Occurring in:
![The deposited structure of PDB entry 2d3o contains 1 copy of SCOP domain 54190 (L23p) in Large ribosomal subunit protein uL23. Showing 1 copy in chain B [auth R].](https://www.ebi.ac.uk/pdbe/static/entry/2d3o_2_R_SCOP_54190_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2d3o</span> contains 1 copy of SCOP domain <span class='highlight'>54190 (L23p)</span> in <span class='highlight'>Large ribosomal subunit protein uL23</span>. Showing 1 copy in chain <span class='highlight'>B [auth R]</span>.")