› 2ddu

X-ray diffraction
2.05Å resolution

Crystal structure of the third repeat domain of reelin

Released:
DOI: 10.2210/pdb2ddu/pdb
PDB entry 2ddu coloured by chain, front view.
PDB entry 2ddu coloured by chain, side view.
PDB entry 2ddu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography.
Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J
EMBO J 25 3675-83 (2006)
PMID: 16858396

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-178823 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Reelin Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 43.3 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q60841 (Residues: 1222-1597; Coverage: 11%)
Gene names: Reln, Rl
Sequence domains: Reelin subrepeat B
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand CL 1 x CL
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: R32
Unit cell:
a: 129.932Å b: 129.932Å c: 122.485Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.265
Expression system: Cricetulus griseus

Quick links

Citations

2 review citations

RELN Mutations in Autism Spectrum Disorder.
Lammert et al. (2016)
1 more

6 mentions without citation

Structural Insights into Reelin Function: Present and Future.
Ranaivoson et al. (2016)
5 more