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Solution structure of the PTB domain of KIAA1075 protein from human

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF08416
Domain description: Phosphotyrosine-binding domain
Occurring in:
  1. Tensin-2
The deposited structure of PDB entry 2dkq contains 1 copy of Pfam domain PF08416 (Phosphotyrosine-binding domain) in Tensin-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013625
Domain description: Tensin/EPS8 phosphotyrosine-binding domain
Occurring in:
  1. Tensin-2
IPR033929
Domain description: Tensin, phosphotyrosine-binding domain
Occurring in:
  1. Tensin-2
IPR006020
Domain description: PTB/PI domain
Occurring in:
  1. Tensin-2
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Tensin-2

Structure domain

CATH CATH domain
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Tensin-2
The deposited structure of PDB entry 2dkq contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in Tensin-2. Showing 1 copy in chain A.
SCOP SCOP annotation
50755
Class: All beta proteins
Fold: PH domain-like barrel
Superfamily: PH domain-like
Occurring in:
  1. Tensin-2
The deposited structure of PDB entry 2dkq contains 1 copy of SCOP domain 50755 (Phosphotyrosine-binding domain (PTB)) in Tensin-2. Showing 1 copy in chain A.

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