› 2dpr

X-ray diffraction
1.7Å resolution

The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif

Released:
DOI: 10.2210/pdb2dpr/pdb
PDB entry 2dpr coloured by chain, front view.
PDB entry 2dpr coloured by chain, side view.
PDB entry 2dpr coloured by chain, top view.
Source organism: Conus tulipa
Primary publication:
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.
Cnudde SE, Prorok M, Dai Q, Castellino FJ, Geiger JH
J Am Chem Soc 129 1586-93 (2007)
PMID: 17243678

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-148132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Conantokin-T Chains: A, B
Molecule details ›
Chains: A, B
Length: 21 amino acids
Theoretical weight: 2.73 KDa
Source organism: Conus tulipa
Expression system: Not provided
UniProt:
  • Canonical: P17684 (Residues: 1-21; Coverage: 100%)
Sequence domains: Conantokin toxin

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
1 modified residue:
Ligand CGU 10 x CGU

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P4332
Unit cell:
a: 89.013Å b: 89.013Å c: 89.013Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.14 0.133 0.186
Expression system: Not provided

Quick links

Citations

3 review citations

Marine natural products.
Blunt et al. (2009)
2 more

2 mentions without citation

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.
Cnudde et al. (2010)
1 more