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Crystal structure of Leu65 to Ala mutant of Diphthine synthase

Source organism: Pyrococcus horikoshii OT3
Biochemical function: methyltransferase activity
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.98: Diphthine synthase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + 2-((3S)-3-carboxy-3-(methylamino)propyl)-L-histidine-[translation elongation factor 2]
Systematic name:
S-adenosyl-L-methionine:2-((3S)-3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] methyltransferase (diphthine-[translation elongation factor 2]-forming)
Alternative Name(s):
  • Diphthine methyltransferase
  • Dph5
  • S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase
  • S-adenosyl-L-methionine:elongation factor 2 methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00590
Domain description: Tetrapyrrole (Corrin/Porphyrin) Methylases
Occurring in:
  1. Diphthine synthase
The deposited structure of PDB entry 2dv5 contains 2 copies of Pfam domain PF00590 (Tetrapyrrole (Corrin/Porphyrin) Methylases) in Diphthine synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004551
Domain description: Diphthine synthase
Occurring in:
  1. Diphthine synthase
IPR014776
Domain description: Tetrapyrrole methylase, subdomain 2
Occurring in:
  1. Diphthine synthase
IPR000878
Domain description: Tetrapyrrole methylase
Occurring in:
  1. Diphthine synthase
IPR035996
Domain description: Tetrapyrrole methylase superfamily
Occurring in:
  1. Diphthine synthase
IPR014777
Domain description: Tetrapyrrole methylase, subdomain 1
Occurring in:
  1. Diphthine synthase

Structure domains

CATH CATH domains
3.30.950.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Homology: Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Occurring in:
  1. Diphthine synthase
The deposited structure of PDB entry 2dv5 contains 2 copies of CATH domain 3.30.950.10 (Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2) in Diphthine synthase. Showing 1 copy in chain A.
3.40.1010.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Cobalt-precorrin-4 Transmethylase; domain 1
Homology: Cobalt-precorrin-4 Transmethylase; Domain 1
Occurring in:
  1. Diphthine synthase
The deposited structure of PDB entry 2dv5 contains 2 copies of CATH domain 3.40.1010.10 (Cobalt-precorrin-4 Transmethylase; domain 1) in Diphthine synthase. Showing 1 copy in chain A.

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