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HOLO FORM OF A NADP DEPENDENT ALDEHYDE DEHYDROGENASE COMPLEX WITH NADP+

Source organism: Streptococcus mutans
Biochemical function: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.2.1.9: Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))

Reaction catalysed:
D-glyceraldehyde 3-phosphate + NADP(+) + H(2)O = 3-phospho-D-glycerate + NADPH
Systematic name:
D-glyceraldehyde-3-phosphate:NADP(+) oxidoreductase
Alternative Name(s):
  • Dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)
  • Glyceraldehyde 3-phosphate dehydrogenase (NADP)
  • Glyceraldehyde phosphate dehydrogenase (NADP)
  • Glyceraldehyde-3-phosphate:NADP reductase
  • NADP-glyceraldehyde phosphate dehydrogenase
  • NADP-glyceraldehyde-3-phosphate dehydrogenase
  • Nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase
  • Triosephosphate dehydrogenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
The deposited structure of PDB entry 2euh contains 4 copies of Pfam domain PF00171 (Aldehyde dehydrogenase family) in NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016160
Domain description: Aldehyde dehydrogenase, cysteine active site
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase

Structure domains

CATH CATH domains
3.40.605.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 1
Homology: Aldehyde Dehydrogenase; Chain A, domain 1
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
The deposited structure of PDB entry 2euh contains 4 copies of CATH domain 3.40.605.10 (Aldehyde Dehydrogenase; Chain A, domain 1) in NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Showing 1 copy in chain A.
3.40.309.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 2
Homology: Aldehyde Dehydrogenase; Chain A, domain 2
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
The deposited structure of PDB entry 2euh contains 4 copies of CATH domain 3.40.309.10 (Aldehyde Dehydrogenase; Chain A, domain 2) in NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Showing 1 copy in chain A.
SCOP SCOP annotation
53721
Class: Alpha and beta proteins (a/b)
Fold: ALDH-like
Superfamily: ALDH-like
Occurring in:
  1. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
The deposited structure of PDB entry 2euh contains 4 copies of SCOP domain 53721 (ALDH-like) in NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Showing 1 copy in chain A.

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