› 2ew9

Solution NMR

Solution structure of apoWLN5-6

Released:
DOI: 10.2210/pdb2ew9/pdb
PDB entry 2ew9 coloured by chain, ensemble of 31 models, front view.
PDB entry 2ew9 coloured by chain, ensemble of 31 models, side view.
PDB entry 2ew9 coloured by chain, ensemble of 31 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake.
Achila D, Banci L, Bertini I, Bunce J, Ciofi-Baffoni S, Huffman DL
Proc Natl Acad Sci U S A 103 5729-34 (2006)
PMID: 16571664

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WND/140 kDa Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 16.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35670 (Residues: 485-633; Coverage: 10%)
Gene names: ATP7B, PWD, WC1, WND
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Function and regulation of human copper-transporting ATPases.
Lutsenko et al. (2007)
26 more

11 mentions without citation

Structural biology of copper trafficking.
Boal et al. (2009)
10 more