› 2fcg

Solution NMR

Solution structure of the C-terminal fragment of human LL-37

Released:
DOI: 10.2210/pdb2fcg/pdb
PDB entry 2fcg coloured by chain, ensemble of 20 models, front view.
PDB entry 2fcg coloured by chain, ensemble of 20 models, side view.
PDB entry 2fcg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.
Li X, Li Y, Han H, Miller DW, Wang G
J Am Chem Soc 128 5776-85 (2006)
PMID: 16637646

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibacterial peptide LL-23 Chain: F
Molecule details ›
Chain: F
Length: 25 amino acids
Theoretical weight: 3.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49913 (Residues: 146-170; Coverage: 18%)
Gene names: CAMP, CAP18, FALL39, HSD26
Sequence domains: LPS binding domain of CAP18 (C terminal)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

33 review citations

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense.
Lai et al. (2009)
32 more

4 mentions without citation

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments.
Wang et al. (2014)
3 more