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Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit Promoter

Solution NMR
PDB entry 2ff0 coloured by chain, ensemble of 16 models, front view.
PDB entry 2ff0 coloured by chain, ensemble of 16 models, side view.
PDB entry 2ff0 coloured by chain, ensemble of 16 models, top view.
Source organism: Mus musculus
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Steroidogenic factor 1 and DNA
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Multimeric state: hetero trimer
Accessible surface area: 9755.53 Å2
Buried surface area: 4431.27 Å2
Dissociation area: 1,445.87 Å2
Dissociation energy (ΔGdiss): 9 kcal/mol
Dissociation entropy (TΔSdiss): 10.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115253

Macromolecules

Steroidogenic factor 1
Chain: A
Length: 102 amino acids
Theoretical weight: 11.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P33242 (Residues: 10-111; Coverage: 22%)
Gene names: Ftzf1, Nr5a1
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
Steroidogenic factor 1 in PDB entry 2ff0, assembly 1, front view.
Steroidogenic factor 1 in PDB entry 2ff0, assembly 1, side view.
Steroidogenic factor 1 in PDB entry 2ff0, assembly 1, top view.
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DNA chain B
Name: GGCTCAGGGCCACAG
Representative chains: B
Source organism: Mus musculus [10090]
Expression system: Not provided
Length: 15 nucleotides
Theoretical weight: 4.62 KDa
GGCTCAGGGCCACAG in PDB entry 2ff0, assembly 1, front view.
GGCTCAGGGCCACAG in PDB entry 2ff0, assembly 1, side view.
GGCTCAGGGCCACAG in PDB entry 2ff0, assembly 1, top view.
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DNA chain C
Name: CTGTGGCCCTGAGCC
Representative chains: C
Source organism: Mus musculus [10090]
Expression system: Not provided
Length: 15 nucleotides
Theoretical weight: 4.56 KDa
CTGTGGCCCTGAGCC in PDB entry 2ff0, assembly 1, front view.
CTGTGGCCCTGAGCC in PDB entry 2ff0, assembly 1, side view.
CTGTGGCCCTGAGCC in PDB entry 2ff0, assembly 1, top view.
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