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Crystal structure of a BPTI variant (Cys14->Ser) in complex with trypsin

Source organism: Bos taurus
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: digestion
Cellular component: serine protease inhibitor complex

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EC 3.4.21.4: Trypsin

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Systematic name:
-
Alternative Name(s):
  • Alpha-trypsin
  • Beta-trypsin
  • Cocoonase
  • Parenzyme
  • Parenzymol
  • Pseudotrypsin
  • Sperm receptor hydrolase
  • Tripcellim
  • Tryptar
  • Tryptase
  • Trypure

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00014
Domain description: Kunitz/Bovine pancreatic trypsin inhibitor domain
Occurring in:
  1. Pancreatic trypsin inhibitor
The deposited structure of PDB entry 2fi4 contains 1 copy of Pfam domain PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) in Pancreatic trypsin inhibitor. Showing 1 copy in chain B [auth I].

PF00089
Domain description: Trypsin
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 2fi4 contains 1 copy of Pfam domain PF00089 (Trypsin) in Serine protease 1. Showing 1 copy in chain A [auth E].

InterPro InterPro annotations
IPR002223
Domain description: Pancreatic trypsin inhibitor Kunitz domain
Occurring in:
  1. Pancreatic trypsin inhibitor
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Serine protease 1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Serine protease 1
IPR036880
Domain description: Pancreatic trypsin inhibitor Kunitz domain superfamily
Occurring in:
  1. Pancreatic trypsin inhibitor
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Serine protease 1
IPR020901
Domain description: Proteinase inhibitor I2, Kunitz, conserved site
Occurring in:
  1. Pancreatic trypsin inhibitor
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Serine protease 1
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Serine protease 1
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Serine protease 1

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 2fi4 contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Serine protease 1. Showing 2 copies in chain A [auth E].
4.10.410.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Factor Xa Inhibitor
Homology: Pancreatic trypsin inhibitor Kunitz domain
Occurring in:
  1. Pancreatic trypsin inhibitor
The deposited structure of PDB entry 2fi4 contains 1 copy of CATH domain 4.10.410.10 (Factor Xa Inhibitor) in Pancreatic trypsin inhibitor. Showing 1 copy in chain B [auth I].
SCOP SCOP annotations
57363
Class: Small proteins
Fold: BPTI-like
Superfamily: BPTI-like
Occurring in:
  1. Pancreatic trypsin inhibitor
The deposited structure of PDB entry 2fi4 contains 1 copy of SCOP domain 57363 (Small Kunitz-type inhibitors & BPTI-like toxins) in Pancreatic trypsin inhibitor. Showing 1 copy in chain B [auth I].
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 2fi4 contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Serine protease 1. Showing 1 copy in chain A [auth E].

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